Clinical and laboratory signs of systemic inflammation, including changes in body temperature, tachycardia, or leukocytosis, are neither sensitive nor specific enough for the diagnosis of sepsis. This issue is of paramount importance because therapy and outcomes differ greatly between patients with and those without sepsis. Microbiological culture can be used to distinguish sepsis from non-infectious conditions. However, this method lacks sensitivity and specificity, and there is often a substantial time delay. Indiscriminate use of broad-spectrum antibiotics for patients with SRIS but without sepsis has led to the development of resistant strains and increased toxicity and cost.

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Respuesta inflamatoria local normal. Esto nos conduce a la segunda posibilidad. En base a los mediadores sintetizados por los linfocitos T colaboradores CD4 activados, se distinguen dos familias de linfocitos T. Las altas dosis de estas linfocinas son letales.

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Síndrome de respuesta inflamatoria sistémica



Síndrome da resposta inflamatória sistêmica



Síndrome de disfunción multiorgánica


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